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Friday, November 16, 2018

Molecular Biology - Fifth Edition - By "Robert F. Weaver"

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What is molecular biology? The term has more than one defi nition. Some define it very broadly as the attempt to understand biological phenomena in molecular terms. But this defi nition makes molecular biology diffi cult to distinguish from another well-known discipline, biochemistry. Another definition is more restrictive and therefore more useful: the study of gene structure and function at the molecular level. This attempt to explain genes and their activities in molecular terms is the subject matter of this book. Molecular biology grew out of the disciplines of genetics and biochemistry. In this chapter we will review the major early developments in the history of this hybrid discipline, beginning with the earliest genetic experiments performed by Gregor Mendel in the mid-nineteenth century .
The most obvious change in the fi fth edition is the splitting of old Chapter 24 (Genomics, Proteomics, and Bioinformatics) in two. This chapter was already the longest in the book, and the field it represents is growing explosively, so a split was inevitable. The new Chapter 24 deals with classical genomics: the sequencing and comparison of genomes. New material in Chapter 24 includes an analysis of the similarity between the human and chimpanzee genomes, and a look at the even closer similarity between the human and Neanderthal genomes, including recent evidence for interbreeding between humans and Neanderthals. It also includes an update on the new fi eld of synthetic biology, made possible by genomic work on microorganisms, and contains a report of the recent success by Craig Venter and colleagues in creating a living Mycoplasma cell with a synthetic genome.

About the Author
Guide to Experimental Techniques in Molecular Biology
PART I: Introduction
1 A Brief History
2 The Molecular Nature of Genes
3 An Introduction to Gene Function
PART II: Methods in Molecular Biology
4 Molecular Cloning Methods
5 Molecular Tools for Studying Genes and Gene Activity
PART III: Transcription in Bacteria
6 The Mechanism of Transcription in Bacteria
7 Operons: Fine Control of Bacterial Transcription
8 Major Shifts in Bacterial Transcription
9 DNA–Protein Interactions in Bacteria
PART IV: Transcription in Eukaryotes
10 Eukaryotic RNA Polymerases and Their Promoters
11 General Transcription Factors in Eukaryotes
12 Transcription Activators in Eukaryotes
13 Chromatin Structure and Its Effects on Transcription
PART V: Post-Transcriptional Events
14 RNA Processing I: Splicing
15 RNA Processing II: Capping and Polyadenylation
16 Other RNA Processing Events and Post-Transcriptional Control of Gene Expression
PART VI: Translation
17 The Mechanism of Translation I: Initiation
18 The Mechanism of Translation II: Elongation and Termination
19 Ribosomes and Transfer RNA
PART VII: DNA Replication, Recombination, and Transposition
20 DNA Replication, Damage, and Repair
21 DNA Replication II: Detailed Mechanism
22 Homologous Recombination
23 Transposition
PART VIII: Genomes
24 Introduction to Genomics: DNA Sequencing on a Genomic Scale
25 Genomics II: Functional Genomics, Proteomics, and Bioinformatics

Author Details
"Rob Weaver" was born in Topeka, Kansas, and grew up in Arlington, Virginia. He received his
bachelor’s degree in chemistry from the College of Wooster in Wooster, Ohio, in 1964. He earned his Ph.D. in biochemistry at Duke University in 1969, then spent two years doing postdoctoral research at the University of California, San Francisco, where he studied the structure of eukaryotic RNA polymerases with William J. Rutter. 
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