Tuesday, April 23, 2019

Biochemistry (Free PDF)

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For more than 25 years, and through four editions, Stryer's Biochemistry has laid out this beautiful subject in an exceptionally appealing and lucid manner. The engaging writing style and attractive design have made the text a pleasure for our students to read and study throughout our years of teaching. Thus, we were delighted to be given the opportunity to participate in the revision of this book. The task has been exciting and somewhat daunting, doubly so because of the dramatic changes that are transforming the field of biochemistry as we move into the twenty-first century. Biochemistry is rapidly progressing from a science performed almost entirely at the laboratory bench to one that may be explored through computers. The recently developed ability to determine entire genomic sequences has provided the data needed to accomplish massive comparisons of derived protein sequences, the results of which may be used to formulate and test hypotheses about biochemical function. The power of these new methods is explained by the impact of evolution: many molecules and biochemical pathways have been generated by duplicating and modifying existing ones. Our challenge in writing the fifth edition of Biochemistry has been to introduce this philosophical shift in biochemistry while maintaining the clear and inviting style that has distinguished the preceding four editions.

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I. The Molecular Design of Life
1. Prelude: Biochemistry and the Genomic Revolution
2. Biochemical Evolution
3. Protein Structure and Function
4. Exploring Proteins
5. DNA, RNA, and the Flow of Genetic Information
6. Exploring Genes
7. Exploring Evolution
8. Enzymes: Basic Concepts and Kinetics
9. Catalytic Strategies
10. Regulatory Strategies: Enzymes and Hemoglobin
11. Carbohydrates
12. Lipids and Cell Membranes
13. Membrane Channels and Pumps
II. Transducing and Storing Energy
14. Metabolism: Basic Concepts and Design
15. Signal-Transduction Pathways: An Introduction to Information Metabolism
16. Glycolysis and Gluconeogenesis
17. The Citric Acid Cycle
18. Oxidative Phosphorylation
19. The Light Reactions of Photosynthesis
20. The Calvin Cycle and the Pentose Phosphate Pathway
21. Glycogen Metabolism
22. Fatty Acid Metabolism
23. Protein Turnover and Amino Acid Catabolism
III. Synthesizing the Molecules of Life
24. The Biosynthesis of Amino Acids
25. Nucleotide Biosynthesis
26. The Biosynthesis of Membrane Lipids and Steroids
27. DNA Replication, Recombination, and Repair
28. RNA Synthesis and Splicing
29. Protein Synthesis
30. The Integration of Metabolism
31. The Control of Gene Expression
IV. Responding to Environmental Changes
32. Sensory Systems
33. The Immune System
34. Molecular Motors
Appendix A: Physical Constants and Conversion of Units
Appendix B: Acidity Constants
Appendix C: Standard Bond Lengths
Glossary of Compounds
Answers to Problems
Common Abbreviations in Biochemistry

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