Thursday, May 30, 2019

Essentials of Pharmaceutical Preformulation

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The inspiration for this book came when Michael Aulton asked me to take over his preformulation module on the PIAT course of the University of Manchester. The existing module was based on the excellent textbook (Pharmaceutical Preformulation) written by Jim Wells in 1988 and thus a perfect opportunity to write both an updated module and an updated book presented itself.

The majority of the text was written while I was on sabbatical leave at the Monash Institute for Pharmaceutical Sciences (MIPS) in Melbourne, Australia, in the summer of 2011. I am hugely grateful to Prof. Bill Charman, Prof. Peter Stewart, Marian Costelloe and Marian Glennon for arranging the visit and to MIPS as a whole for the welcoming, friendly and stimulating environment they provided. I would also like to mention many of the wonderful people that I met, including Anne, Ben, Carolyn, Chris, Colin, David, Ian, Hywel, Iliana, Joe, Laurence, Mercedes and Michelle. Special thanks are reserved for Richard Prankerd, who took the time and effort to talk with me about many aspects of the text while I was at MIPS and also to review the whole text before publication; the book is immeasurably better for his input and advice. Thermal analysts are indeed a special breed!

List of Abbreviations
1. Basic Principles of Preformulation Studies
2. Ionisation Constants
3. Partition Affinity
4. Solubility
5. Dissolution
6. Salt Selection
7. Physical Form I – Crystalline Materials
8. Physical Form II – Amorphous Materials
9. Stability Assessment
10. Particle Properties
11. Powder Properties

Author Details
"Simon Gaisford"
UCL School of Pharmacy, University College London, London, UK

"Mark Saunders"
Kuecept Ltd, Potters Bar, Herts, UK

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