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For some 30 years I taught a graduate-level course in heterocyclic chemistry at Duke University and later at the University of Massachusetts. Then in 1997 I was given the opportunity at the University of North Carolina Wilmington to tailor the level of the course so as to be appropriate for undergraduates who had completed only the basic two-semester course in organic chemistry. This new one-semester course was described as a special topics course and met a curriculum requirement. The course was also open to first-year graduate students working toward the M.S. degree.This book grew out of the lectures in that course. The subject is of course enormous, and the course had to be designed to introduce an appreciation of the vast number of parent heterocyclic systems and the importance of their derivatives (especially in medicine), both in synthetic and in natural structures, without going into excessive detail. Similarly, fundamental aspects of synthesis of representative ring systems and of their special properties as heterocycles were topics given major attention but again without going into the great detail found in more advanced books on this subject. After the first offering of the course, it was apparent that the students would benefit from a brief review of some of the reactions and properties they had encountered in their basic organic course before these were applied to heterocyclic systems. Such reviews are included in this book.
Content:-
PREFACE
ACKNOWLEDGMENT
Chapter 1: THE SCOPE OF THE FIELD OF HETEROCYCLIC CHEMISTRY
Chapter 2: COMMON RING SYSTEMS AND THE NAMING OF HETEROCYCLIC COMPOUNDS
Chapter 3: NATURE AS A SOURCE OF HETEROCYCLIC COMPOUNDS
Chapter 4: PRINCIPLES OF SYNTHESIS OF AROMATIC HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION
Chapter 5: SYNTHESIS OF HETEROCYCLIC SYSTEMS BY CYCLOADDITION REACTIONS
Chapter 6: AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-DEFICIENT RING SYSTEMS
Chapter 7: AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES:
PI-EXCESSIVE RING SYSTEMS AND MESOIONIC RING SYSTEMS
Chapter 8: THE IMPORTANCE OF HETEROCYCLES IN MEDICINE
Chapter 9: SYNTHETIC METHODS FOR SOME PROMINENT HETEROCYCLIC FAMILIES: EXAMPLES OF PHARMACEUTICALS SYNTHESIS
Chapter 10: GEOMETRIC AND STEREOCHEMICAL ASPECTS OF NONAROMATIC HETEROCYCLES
Chapter 11: SYNTHETIC HETEROCYCLIC COMPOUNDS IN AGRICULTURAL AND OTHER APPLICATIONS
Appendix. UNIFIED AROMATICITY INDICES (IA) OF BIRD
INDEX
Author Details
"LOUIS D. QUIN" Adjunct Professor, University of North Carolina Wilmington James B. Duke Professor Emeritus, Duke University Professor Emeritus, The University of Massachusetts."JOHN A. TYRELL", PH.D. University of North Carolina Wilmington.
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