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Clinical pharmacology is the science of drug use in humans. Clinicians of all specialties prescribe drugs on a daily basis, and this is both one of the most useful but also one of the most dangerous activities of our professional lives. Understanding the principles of clinical pharmacology is the basis of safe and effective therapeutic practice, which is why this subject forms an increasingly important part of the medical curriculum.This textbook is addressed primarily to medical students and junior doctors of all specialties, but also to other professionals who increasingly prescribe medicines (including pharmacists, nurses and some other allied professionals). Clinical pharmacology is a fast moving subject and the present edition has been completely revised and updated. It differs from the fourth edition in that it concentrates exclusively on aspects that students should know and understand, rather than including a lot of reference material. This has enabled us to keep its length down. Another feature has been to include many new illustrations to aid in grasping mechanisms and principles.
Content:-
FOREWORD
PREFACE
ACKNOWLEDGEMENTS
PART I GENERAL PRINCIPLES
1. Introduction to therapeutics
2. Mechanisms of drug action (pharmacodynamics)
3. Pharmacokinetics
4. Drug absorption and routes of administration
5. Drug metabolism
6. Renal excretion of drugs
7. Effects of disease on drug disposition
8. Therapeutic drug monitoring
9. Drugs in pregnancy
10. Drugs in infants and children
11. Drugs in the elderly
12. Adverse drug reactions
13. Drug interactions
14. Pharmacogenetics
15. Introduction of new drugs and clinical trials
16. Cell-based and recombinant DNA therapies
17. Alternative medicines: herbals and nutraceuticals
PART II THE NERVOUS SYSTEM
18. Hypnotics and anxiolytics
19. Schizophrenia and behavioural emergencies
20. Mood disorders
21. Movement disorders and degenerative CNS disease
22. Anti-epileptics
23. Migraine
24. Anaesthetics and muscle relaxants
25. Analgesics and the control of pain
PART III: THE MUSCULOSKELETAL SYSTEM
26. Anti-inflammatory drugs and the treatment of arthritis
PART IV: THE CARDIOVASCULAR SYSTEM
27. Prevention of atheroma: lowering plasma cholesterol and other approaches
28. Hypertension
29. Ischaemic heart disease
30. Anticoagulants and antiplatelet drugs
31. Heart failure
32. Cardiac dysrhythmias
PART V: THE RESPIRATORY SYSTEM
33. Therapy of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory disorders
PART VI: THE ALIMENTARY SYSTEM
34. Alimentary system and liver
35. Vitamins and trace elements
PART VII: FLUIDS AND ELECTROLYTES
36. Nephrological and related aspects
PART VIII: THE ENDOCRINE SYSTEM
37. Diabetes mellitus
38. Thyroid
39. Calcium metabolism
40. Adrenal hormones
41. Reproductive endocrinology
42. The pituitary hormones and related drugs
PART IX: SELECTIVE TOXICITY
43. Antibacterial drugs
44. Mycobacterial infections
45. Fungal and non-HIV viral infections
46. HIV and AIDS
47. Malaria and other parasitic infections
48. Cancer chemotherapy
PART X: HAEMATOLOGY
49. Anaemia and other haematological disorders
PART XI IMMUNOPHARMACOLOGY
50. Clinical immunopharmacology
PART XII: THE SKIN
51. Drugs and the skin
PART XIII: THE EYE
52. Drugs and the eye
PART XIV: CLINICAL TOXICOLOGY
53. Drugs and alcohol abuse
54. Drug overdose and poisoning
INDEX
Author Details
"JAMES M RITTER" MA DPHIL FRCP FMedSci FBPHARMACOLS Professor of Clinical Pharmacology at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK"LIONEL D LEWIS" MA MB BCH MD FRCP Professor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School and the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
"TIMOTHY GK MANT" BSC FFPM FRCP Senior Medical Advisor, Quintiles, Guy's Drug Research Unit, and Visiting Professor at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK
"ALBERT FERRO" PHD FRCP FBPHARMACOLS Reader in Clinical Pharmacology and Honorary Consultant Physician at King’s College London School of Medicine, Guy’s, King’s and St Thomas’ Hospitals, London, UK
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